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TLC Formula:
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Total Lymphocyte Count (TLC) is a calculation that estimates the absolute number of lymphocytes in the blood. It is derived from the white blood cell count and the percentage of lymphocytes in the differential count.
The calculator uses the TLC formula:
Where:
Explanation: The formula calculates the absolute lymphocyte count by multiplying the total white blood cell count by the percentage of lymphocytes divided by 100.
Details: TLC is an important parameter in assessing immune function, monitoring immune status in various diseases, and evaluating nutritional status. It is particularly useful in conditions like HIV/AIDS, malnutrition, and following chemotherapy.
Tips: Enter WBC count in cells/μL and lymphocytes percentage (%). Both values must be valid (WBC > 0, lymphocytes between 0-100%).
Q1: What is a normal TLC range?
A: Normal TLC typically ranges from 1,000 to 4,800 cells/μL in adults, though this can vary by age and laboratory reference ranges.
Q2: Why is TLC important in clinical practice?
A: TLC helps assess immune competence, monitor disease progression in immunodeficiencies, and evaluate response to treatments affecting the immune system.
Q3: When should TLC be measured?
A: TLC should be measured when evaluating immune function, monitoring patients with known immune disorders, or assessing nutritional status in malnourished patients.
Q4: Are there limitations to TLC calculation?
A: TLC provides an estimate and should be interpreted in clinical context. It doesn't differentiate between lymphocyte subtypes (T-cells, B-cells, NK cells).
Q5: How does TLC relate to other immune parameters?
A: TLC is often used alongside other tests like CD4 count in HIV patients or lymphocyte subset analysis for a more comprehensive immune assessment.